Evidence of organ damage after cardiopulmonary bypass
نویسندگان
چکیده
منابع مشابه
Cardiopulmonary Bypass - "evidence-based medicine"?
The purpose of this study was to evaluate the amount and quality of scientific evidence supporting principles that are currently applied for cardiopulmonary bypass (CPB) performance. The scientific data concerning the effectiveness and safety of key principles of cardiopulmonary bypass is insufficient in both amount and quality to serve as a basis for practical, evidence-based guidelines.
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The objective of this study was to investigate whether hypertonic hyperosmolar primes solution (HHPS), with an osmolarity of 2300 mOsmol/L, causes endothelial damage/loss. The bodies' normal osmolarity is -280 mOsmol/L. Aortic endothelial cells were cultured and plated to confluence, confirmed by light microscopy, on a 96-well plate. Serial dilutions of HHPS (n = 10) were incubated with the cel...
متن کاملLung injury after cardiopulmonary bypass.
Pulmonary injury during cardiopulmonary bypass is common as patient factors (smoking, pain, pneumonia) and the effects of cardiopulmonary bypass combine to compromise lung function after cardiac surgery. Lung injury follows the propagation of an inflammatory response involving cytokines, complement, neutrophils, monocytes, activated endothelial cells and platelets. Neutrophils sequester in the ...
متن کاملNadir hematocrit during cardiopulmonary bypass: end-organ dysfunction and mortality.
OBJECTIVE To discover the effects of the lowest hematocrit during cardiopulmonary bypass on end-organ function and mortality in patients who did not receive red blood cell transfusion and to identify predictors of nadir hematocrit. METHODS From November 1, 2004, to October 1, 2009, 7957 patients underwent cardiac surgery supported by cardiopulmonary bypass and were not transfused. The relatio...
متن کاملCirculating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass: a prospective observational study
INTRODUCTION Cardiovascular surgery with cardiopulmonary bypass (CPB) has improved in past decades, but inflammatory activation in this setting is still unpredictable and is associated with several postoperative complications. Perioperative levels of macrophage migration inhibitory factor (MIF) and other inflammatory mediators could be implicated in adverse outcomes in cardiac surgery. METHOD...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1992
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)34734-8